import pandas as pd
import numpy as np

filename = 'hugedatafile.csv'
nlinesfile = 10000000
nlinesrandomsample = 10000
lines2skip = np.random.choice(np.arange(1,nlinesfile+1), (nlinesfile-nlinesrandomsample), replace=False)
df = pd.read_csv(filename, skiprows=lines2skip)