In [15]: df = pd.DataFrame([1, 2, 3], index=[dt.datetime(2013, 1, 1), dt.datetime(2013, 1, 3), dt.datetime(2013, 1, 5)])

In [16]: df
Out[16]: 
            0
2013-01-01  1
2013-01-03  2
2013-01-05  3

In [22]: start = df.index.searchsorted(dt.datetime(2013, 1, 2))

In [23]: end = df.index.searchsorted(dt.datetime(2013, 1, 4))

In [24]: df.iloc[start:end]
Out[24]: 
            0
2013-01-03  2