//Here is the variable with which you assign a new value to the attribute
string newValue = string.Empty;
XmlDocument xmlDoc = new XmlDocument();

xmlDoc.Load(xmlFile);

XmlNode node = xmlDoc.SelectSingleNode("Root/Node/Element");
node.Attributes[0].Value = newValue;

xmlDoc.Save(xmlFile);

//xmlFile is the path of your file to be modified